MDhair Review - Does This Custom Hair Regrowth Treatment Work? (2023)

What Is MDhair?

MDhair is a hair-care company that provides personalized hair growth treatment supplements, products, and plans that target specific root causes of hair loss.

The brand’s products are available either through one-time purchases or through subscriptions where you get unlimited online access to service and treatment by a dermatologist.

MDhair provides an online platform where consumers get personalized hair regrowth care through products. The platform offers recommendations for the best hair regrowth products based on information shared by the consumer on hair type, gender, hair loss, and other features.

The company’s mission is to ensure it creates a personalized hair growth treatment plan that is easily accessible to customers. AL technology has facilitated accessibility as customers can easily ask medical-related questions and receive treatment plan feedback within no time.

Fast Facts

MDhair

MDhair BackgroundFounded in 2021 by DR.Yoram Harth, a certified dermatologist, and Oded Harth, his son who is an AL specialist. FDA-approved, sulfate, phthalate, and paraben free
Best for:Hair regrowth treatment plans and products.
Key IngredientsBiotin, Saw palmetto, Minoxidil, collagen, vitamins and minerals such as B6 and Zinc, DHT blockers, Pumpkin seed oil,
Price Range$22- $48

How Does It Work?

MDhair products definitely work as customers are recommended products based on the root causes of hair loss and not just a broad recommendation of products. The quiz requires customers to feel in questions on gender, hair goals, age, hair type, and hair care routines.

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*All individuals are unique. Your results can and will vary.

In less than 1 minute, you get the best recommendations that will directly address the cause of your hair loss. A custom treatment kit is formulated to cater to your specific hair needs.

(Video) How To REGROW Your Hair *Healthy & Long* For ALL Hair Types | MDHAIR REVIEW + DEMO

The uniqueness of the MDhair brand is that you receive unlimited dermatologist support for any hair-conditions concerns. MDhair growth products contain DHT blockers that suppress the DHT hormone responsible for preventing the proper growth of hair.

According to a Journal of Cosmetic Dermatology DHT, blockers are an effective medication for treating androgenetic alopecia and hair loss conditions in both men and women characterized by hair thinning and frontal hairline retention.

MDhair products contain Minoxidil which is very effective in dealing with problems that cause difficulty in hair regrowth. An article by Dr. Venkaratam Mysore from The Venkat Center for Skin and Plastic Surgery shows that Minoxidil can be used as therapy for androgenetic alopecia in men and as treatment for female pattern loss. (source)

What Are the Best-Selling MDhair Products?

1. MDhair Customized Hair Care Serum

The secret to shiny, healthy hair is through the right serum. The serum promotes hair growth and increases hair follicle size. It is formulated for stress-related hair loss and postpartum.

Some of the ingredients include: Copper peptides, biotin, and saw palmetto extract as the main ingredients. Studies show that saw palmetto contains similar properties to finasteride medication for hair loss.

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*All individuals are unique. Your results can and will vary.

The serum is free from fragrance and suitable also for individuals with colored hair. MDhair recommends using the serum at least once daily and leaving it to set for 4 hours before washing it off the hair

2. MDhair customized hair regrowth treatment (Minoxidil 2.0%)

A hair regrowth treatment is recommended for women. Approved by the FDA in the treatment of androgenic alopecia. It also addresses other hair loss causes such as alopecia areata and chemotherapy-induced alopecia.

The product is to be used twice a day with a drop placed directly on the scalp. Minoxidil 2.0% is cruelty-free. It is also appropriate for individuals of all skin types.

3. MDhair Regrowth Shampoo

The use of shampoo is a critical step in the hair care routine. The regrowth shampoo contains ingredients such as biotin, argan oils, pumpkin seed oil, probiotics, and 20 other plant compounds that promote hair regrowth.

Hydrolyzed rice proteins contained in the shampoo help calm hair dryness and minimize build-up. Regrowth shampoo is formulated to reduce hair breakage and frizz.

(Video) I used a CUSTOM HAIR TREATMENT from MDHAIR for 6 weeks on my fine, thin hair

MDhair recommends washing the hair with regrowth shampoo for at least 1-2, leaving the shampoo 2 minutes before rinsing.

4. MDhair Customized Hair Wellness Supplements

MDhair vegan supplements contain ingredients such as mushroom extract that help protect the hair from sun damage. Vitamin deficiency may cause hair loss hence the wellness supplement is enriched with vitamins B, D, calcium, and zinc that promote hair regrowth.

The supplements contain DHT-blocking ingredients such as saw palmetto, and adaptogenic mushrooms that aid reduce oxidative damage and stress-related hair loss.

5. MDhair Marine Collagen

Collagen is a building block that can help improve the quality of healthy hair. MDhair collagen is mostly obtained from the sea.

The supplement contains hyaluronic acid and vitamin C that aid hydrate and moisturizing the hair. Marine collagen contains no added sugar and is non-GMO.

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*All individuals are unique. Your results can and will vary.

What Are the Ingredients in MDhair Products?

Saw Palmetto

Hormonal change is among the factors that cause hair loss. Saw palmetto is used to balance the body’s hormonal levels.

A study indicates that saw palmetto inhibits the activity of 5-alpha reductase that converts testosterone hormone into DHT associated with hair loss.

Pumpkin Seed Oil

Pumpkin seed contains nutrients, vitamins, and minerals such as zinc, omega-3, magnesium, and fatty acids which are essential for healthy hair. Magnesium helps prevent hair breakage while zinc helps keep the scalp healthy.

Pumpkin is effective in reducing hair loss as it contains cucurbitin a component that inhibits the action of enzyme 5-alpha-reductase. The enzyme is responsible for converting testosterone hormone to DHT which causes hair loss.

Biotin

Biotin also known as Vitamin H promotes keratin synthesis an essential protein for hair growth. It also prevents hair from becoming brittle and weak while also improving the state of hair follicles.

(Video) How to REGROW your hair FAST with MDhair Custom Hair Regrowth Treatment | Amazing results

Supplements that contain biotin often aid regulate sebum, and dandruff and enhance hair growth.

Vitamin C

According to Dr.Enrizza Factor, a clinical dermatologist, Vitamin C is a soluble vitamin obtained from glucose metabolism. Vitamin C supports collagen production which is essential in hair growth.

Pros and Cons of MDhair

Pros

  1. Products are free from parabens, phthalates, and sulfates
  2. The kits are customized based on individual hair loss needs
  3. Access to professional support that is through the subscription program
  4. Products are available over the counter and no need for prescription

Cons

  1. The time period of experiencing results may differ from one individual to another
  2. Subscription costs gradually increase after the initial month
  3. No free samples provided
  4. Products come in only one size

What is the Return Policy for MDhair?

MDhair provided a return policy of only 10 days after delivery. However, the goods have to be unopened and purchased for the first time.

Customers are provided with a place to return the goods that is quite different from the place they collected the order. Unfortunately, most products are refundable as they cannot be used once returned by the customer.

How Does MDhair Rate?

FeatureRatingComments
Safety4.8/5MDhair products are tested to significantly deal with hair loss. The products are cruelty-free, GMO-free, free from sulfate, parabens, and phthalates
Performance4.9/5The products work effectively as they are customized based on individual hair loss needs.
Average customer ratings4.5/5Some customers found the products to be very helpful in minimizing hair loss while other did not benefit more from the products. Reviews are generally balanced.

People Also Ask

Q: Is MDhair a Safe Product Line?

A: The products in this line are supposedly 100 % safe and the ingredients go through rigorous testing. They are also suitable for all hair types including colored hair.

Q: Who Should Use MDhair?

A: MDhair products are suitable for both males and females experiencing hair loss. The products address genetic, stress, and age-related hair loss.

The company, however, advises that hair regrowth may take a while and therefore customers should consider subscribing to the products for several months.

(Video) Customized Hair Regrowth Treatment | MDhair

Q: Who Manufacturers MDhair?

A: MDhair company manufactured by MDhair company founded by Yoram Harth a dermatologist and his son Oded Harth an entrepreneur trained in Artificial Intelligence (AI)

Q: Are MDhair Products Safe During Pregnancy?

A: The company cautions against using the products while pregnant or breastfeeding

How Are the Reviews for MDhair?

The fact that this brand has customer feedback shows it has been in the market for some time. Some of its users say:

“ I have struggled with hair thinning since my 20s. I was skeptical at first about trying MDhair products but I was happy after witnessing great results. My hair is now fuller, healthier, and stronger. What I loved most about MDhair is the 24/7 dermatologist support and the individual customized treatment plan. I highly recommend MDhair products. Alina

“I was impressed after trying out the products. Unlike other products, I had tried before I can attest that the products are quite effective especially after trying them for a couple of months. -Joel

“I feel more confident with my head fuller of hair unlike before when I had to always have a scarf around my head. The ingredients are well-researched to support hair regrowth. Thanks, MDhair company. -Mitchell

Conclusion

Hair care is as important as facial care, as they majorly dictate how you look and you just can’t get it wrong. Hair growth is influenced by a number of factors including genetics and age.

Have you tried other products before with no results, MDhair ascertains its customers of improved hair growth and appearance. MDhair products are GMO- free, and suitable for all genders, and hair types. The products are also free from sulfates and parabens.

One unique thing that should make you consider trying MDhair products is that they provide an individualized treatment plan that ensures to target the root cause of your hair loss. MDhair company also provides unlimited dermatologist support for any hair treatment concerns which is quite different from other brands.

Worth noting, it might be a while before you experience results hence suitable to select the subscription plan for sure results. You should try out MDhair products today

9 Sources

[1] Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9298335/
[2] Expert consensus on the management of Androgenetic Alopecia in India https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580804/
[3] Saw Palmetto https://www.nccih.nih.gov/health/saw-palmetto
[4] Minoxidil and its use in hair disorders: a review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691938/
[5] An update on Plant Derived Anti-Androgens https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/
[6] High-Performance Conditioning Shampoo with Hyaluronic Acid and Sustainable Surfactants https://www.mdpi.com/2079-9284/8/3/71
[7] Determination of the potency of a novel saw palmetto supercritical CO2 extract ( SPSE) for 5a-reductase isoform II inhibition using a cell-free in vitro test system https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847595/
[8] Beneficial effects of pumpkin seed oil as a topical hair growth promoting agent in a mice model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823528/
[9] Biotin https://www.ncbi.nlm.nih.gov/books/NBK554493/

(Video) Customized Hair Regrowth Treatment | MDhair

FAQs

Does MDhair regrowth work? ›

Does MD hair work? There is mixed evidence that the ingredients in MDhair's products can benefit hair growth. For example, topical minoxidil can increase hair growth, with people experiencing the most results after using this product for 1 year .

How long does it take for MDhair to work? ›

Great shampoo for women with hair loss. I have been using this for four months, but it takes at least three months to really start noticing the difference. It's perfect for people that use minoxidil or other scalp serums.

What are the side effects of MDhair? ›

chest pain, rapid heartbeat, faintness, or dizziness occurs - sudden, unexplained weight gain occurs - your hands or feet swell - scalp irritation or redness occurs - unwanted facial hair growth ... May be harmful if used when pregnant or breast-feeding. May be harmful if used when pregnant or breast-feeding.

What is the number 1 Hair Regrowth Treatment? ›

Our best overall pick is Rogaine's Women's 5% Minoxidil Topical Aerosol Hair Regrowth Treatment for its high concentration of active, clinically proven growth ingredients.

Is MDhair FDA approved? ›

Hair growth

The topical medication is FDA-approved and works to regrow thicker and stronger hair. It's also vegan, cruelty-free, safe for color-treated hair, and free from fragrance. You'll also find this treatment available in a 2.0% formula, which the brand recommends for women with age-related or genetic hair loss.

What is the most proven way to grow hair back? ›

10 ways you can make your hair grow back
  • Have a diet with plenty of protein. ...
  • Take the right vitamins. ...
  • Try natural vegetable juice treatments. ...
  • Get regular scalp massages. ...
  • Check with your doc about Finasteride. ...
  • Treat your hair as little as possible. ...
  • Include Biotin in your diet. ...
  • Avoid tight hairstyles.
Sep 6, 2022

What will regrow women's hair? ›

Minoxidil (Rogaine) is approved by the FDA for female pattern hair loss. It can slow or stop it in most women and may help hair grow back. But the benefits go away when you stop using it. Corticosteroids can help regrow hair for women with alopecia areata.

What is the best over the counter shampoo for thinning hair? ›

Our best overall pick is Biolage Advanced Full Density Thickening Shampoo, which contains biotin, zinc, and a gluco-omega blend to strengthen hair while removing follicle-clogging impurities that can prevent new hair growth.

Does biotin tablets help in hair growth? ›

Biotin, also known as vitamin B7, stimulates keratin production in hair and can increase the rate of follicle growth. It is not stored for long in the body - most of yours is from the foods you eat. In order to be effective, it needs to be consumed.

What is stage 2 hair loss female? ›

Patterns of female hair loss

Type II is characterized by decreased volume and noticeable widening of the mid-line part. Type III describes diffuse thinning, with a see-through appearance on the top of the scalp.

How long does it take for Shapiro MD to work? ›

Hair tends to grow, on average, 0.2 to 0.7 inches per month. While everyone's experience is different, most users report seeing an improvement* in their hair health within the first 6 - 12 months of using Shapiro MD Regrowth Kit. Month 1 - 2 As Shapiro MD's products get to work on nourishing your scalp and.

What is the best hair loss treatment in the world? ›

What's the most effective hair loss treatment? Minoxidil (Rogaine) is regarded as one of the most effective hair loss treatments. Topical minoxidil can be an effective treatment for androgenic hair loss,. Some studies demonstrate improvement in up to 70 percent of users.

What are the only two FDA approved hair loss treatments? ›

Finasteride (Propecia) and Minoxidil (both oral and topical - Rogaine) are the only drugs approved by the FDA to treat pattern baldness (hair loss resulting from hereditary causes).

Can hair regrow after hair fall? ›

You might be able to reverse hair loss, or at least slow it. With some conditions, such as patchy hair loss (alopecia areata), hair may regrow without treatment within a year. Treatments for hair loss include medications and surgery.

Can alopecia grow back hair? ›

In most people, new hair eventually grows back in the affected areas, although this process can take months. Approximately 50 percent of people with mild alopecia areata recover within a year; however, most people will experience more than one episode during their lifetime.

What is the new FDA approved hair loss treatment? ›

Baricitinib oral tablets — developed by Eli Lilly and approved by the U.S. Food and Drug Administration (FDA) earlier this year — is the first systemic treatment for alopecia areata.

What can I put on my bald spot to make it grow? ›

Use Minoxidil

Numerous studies have shown that minoxidil is effective at stimulating hair growth in men with male pattern baldness. It's also effective at treating the patchy bald spots that can develop as a result of alopecia areata.

How do you reopen hair follicles? ›

There are a variety of methods available for the regrowth of hair follicles, from using medication to massaging your scalp to stimulate your hair directly. Currently, the most effective way to reactivate your hair follicles is by using medication, such as finasteride and minoxidil.

What is the best vitamin for thinning hair? ›

“Vitamins are essential for healthy hair growth and may help in preventing hair shedding and thinning,” says Michele Green, M.D., a cosmetic dermatologist in New York. “The best vitamins for hair growth include B vitamins, vitamin D, vitamin E, zinc, biotin and iron.

Does any shampoo regrow hair? ›

“In addition, there's no shampoo that's clinically proven to support hair regrowth.” “In addition, there's no shampoo that's clinically proven to support hair regrowth.”

What foods help regrow hair? ›

The 13 Best Foods for Hair Growth
  • Eggs. Eggs are a great source of protein and biotin, two nutrients that are essential for hair growth. ...
  • Berries. Berries are loaded with beneficial compounds and vitamins that may support hair growth. ...
  • Spinach. ...
  • Fatty fish. ...
  • Sweet potatoes. ...
  • Avocados. ...
  • Nuts. ...
  • Seeds.

What is the most effective treatment for women's hair loss? ›

Minoxidil (Rogaine) is an FDA-approved treatment for female pattern hair loss. It's one of the best-known treatment options for hair loss and has been around since 1991. For women, it's available over the counter as a 2% solution or a 5% foam. It's also available off-label as a pill.

Can thin hair become thick again in females? ›

Here's the hard truth: Little can be done to permanently change the diameter of individual hair strands. Thickening products can do wonders to temporarily plump hair strands, but when it comes down to it, fine hair is genetic and can't be changed.

What lack of vitamin causes hair loss? ›

Only riboflavin, biotin, folate, and vitamin B12 deficiencies have been associated with hair loss.

What is the best product to regrow receding hairline? ›

The most common over-the-counter (OTC) medication for a receding hairline is called minoxidil (Rogaine). This is an off-label use for Rogaine. Research has shown topical minoxidil to work better than a placebo.

What is the main reason for hair loss in females? ›

Family history (heredity). The most common cause of hair loss is a hereditary condition that happens with aging. This condition is called androgenic alopecia, male-pattern baldness and female-pattern baldness.

What is the new treatment hair loss? ›

In June 2022, the FDA approved the first treatment for a type of hair loss in which the immune system attacks hair follicles, known as alopecia areata. The drug, called baricitinib, was already approved for the treatment of another autoimmune disorder, rheumatoid arthritis.

What is better for thinning hair biotin or collagen? ›

Based on different studies, it appears that the better supplement recommended to combat thinning hair and maintaining hair health is biotin over collagen. It's far superior in terms of topical absorption and can be absorbed from many foods as part of a healthy, varied diet.

Can too much biotin cause hair loss? ›

Regular intake of excessive quantities of certain nutrients can cause hair loss in some cases due to a temporary condition known as Telogen Effluvium. However, the effects of too much vitamin B7 - also known as biotin toxicity - remain unconfirmed.

How long after taking biotin will I see hair growth? ›

How fast does biotin work for hair growth? Research pertaining to how quickly vitamins work in the body is limited, however, we have found that some begin to see and experience benefits approximately 30 days after you start taking biotin. It may take up to 90 days or longer for some individuals.

Is female hair loss reversible? ›

Is it reversible? While some forms of AFAB hair loss are temporary, female pattern baldness is permanent and irreversible without treatment. However, proper treatment can stop the hair loss and potentially help regrow some lost hair.

How can I regrow my hair in 3 weeks naturally? ›

Natural hair regrowth treatment options
  1. Massage. Massaging the scalp, which people can combine with hair oils and masks, stimulates the scalp and may improve hair thickness . ...
  2. Aloe vera. Aloe vera has long been used for treating hair loss. ...
  3. Coconut oil. ...
  4. Viviscal. ...
  5. Fish oil. ...
  6. Ginseng. ...
  7. Onion juice. ...
  8. Rosemary oil.

At what age does hair loss slow down? ›

After the age of 30-35, shedding starts slowing down, as the levels of androgens in the blood start reducing. In older men with androgenetic alopecia, the hair loss slows down even more. Hair loss stabilizes together with the gradual decline of androgen levels in the blood.

Does Shapiro MD have side effects? ›

Some Shapiro MD customers have reported mild irritation on the scalp after using the product, but this passes quickly and has not been associated with hair loss or other side effects. For those concerned, an evaluation by a dermatologist may make sense before using any hair loss product.

Is Shapiro MD FDA approved? ›

Shapiro MD Minoxidil 5% Men's Hair Growth Treatment, FDA Approved Serum Promotes Hair Regrowth | 1 Month (2 oz) - Walmart.com.

Should I use Shapiro MD everyday? ›

How To Use Shapiro MD for Hair Loss. Shapiro shampoo and conditioner are pretty gentle and only contain natural ingredients – so you can use them every day. Try the set every day for at least a month and notice the effects!

Is there a hair regrowth product that works? ›

Topical minoxidil—or Rogaine—is effective for both male and female hair loss, as well as hair loss due to chemotherapy, says Rina M. Allawh, MD, a board-certified dermatologist in Pennsylvania. The formula is available in both 2 percent and 5 percent topical solutions and 5 percent foam.

What actually grows hair? ›

Hair grows from a root at the bottom of a follicle under your skin. The blood in your scalp goes to the follicle and supplies oxygen and nutrients to the hair root, which helps your hair grow. As your hair grows, it will push through your skin and pass by an oil gland.

What can doctors prescribe for female hair loss? ›

Hair Loss in Women: Treatments
  • Minoxidil (Rogaine)
  • Androgen Receptor Inhibitors.
  • Estrogen and Progesterone.
  • Oral Contraceptives.
  • Ketoconazole (Nizoral)
  • Finasteride (Propecia, Proscar)
  • Dutasteride (Avodart)
  • Cyproterone Acetate with Ethinyloestradiol (Diane 35, Diane 50)

What is a natural alternative to Rogaine? ›

Other natural solutions that are sometimes touted for having hair growth benefits include onion juice, melatonin, garlic for hair growth, marine proteins, and vitamin E.

Is there a better product than Rogaine? ›

DNC-N® topical spray is the first topical hair-loss treatment to employ Nanoxidil®, a powerful new alternative to minoxidil, a compound with high efficacy, low molecular weight, and no known side effects.” Spectral DCN-N arms men and women with a powerful new tool against hair loss.

What is Pfizer's new drug for alopecia? ›

FDA and EMA Accept Regulatory Submission for Pfizer's Ritlecitinib for Individuals 12 Years and Older with Alopecia Areata.

How can I stop hair loss and regrow hair naturally? ›

Natural Treatments for Hair Loss
  1. Onion Juice. 1/15. The idea is that the sulfur in onion juice helps hair regrowth. ...
  2. Iron. 2/15. This crucial nutrient helps your body make blood, and low levels of it are linked to hair loss. ...
  3. Biotin. 3/15. ...
  4. Zinc. 4/15. ...
  5. Saw Palmetto. 5/15. ...
  6. Aromatherapy. 6/15. ...
  7. Silicon. 7/15. ...
  8. Selenium. 8/15.
Jun 26, 2022

Are there any hair regrowth products that work? ›

Currently, there are two hair growth products that stand above all others, at least when it comes to effectiveness -- the medications finasteride and minoxidil. Both of these medications are approved by the FDA to treat male pattern baldness, which is the most common form of hair loss in men.

How effective is minoxidil in regrowing hair? ›

Effectiveness: Minoxidil works for about 2 out of 3 men. It's most effective if you're under age 40 and have only recently started to lose your hair. How to use it: Twice a day, when your hair is dry, apply minoxidil on your scalp where the hair has started to thin. Then be patient.

Does HGH make hair grow back? ›

HGH is an anabolic hormone. An anabolic hormone is a hormone which builds up rather than breaks down. HGH builds and repairs tissues and thus has an effect on hair cells at the hair root to promote healthy hair growth. The growth hormone stimulates growth instead of hindering it.

What is the only FDA approved ingredient that can help regrow hair? ›

There are only two products that currently are approved by the FDA to increase hair growth and treat different types of hair loss: finasteride and minoxidil.

How can I regrow my thinning hair? ›

Topical drugs.

The FDA has approved minoxidil (Rogaine), available over the counter, as a hair loss treatment for both men and women. It helps thicken hair follicles and promotes hair lengthening. It comes in a liquid or foam that's applied to the scalp.

What is the best over-the-counter treatment for thinning hair? ›

Rogaine Extra Strength 5% Minoxidil Solution

We chose Rogaine as our best overall pick because it's one of the most commonly recommended treatments by dermatologists for addressing hair thinning and loss.

Can minoxidil bring back lost hair? ›

If you're in the earlier stages of hair loss, Minoxidil can help regrow your hair and slow further loss. Originally tested in the 1960s as an oral medication to treat high blood pressure, Minoxidil was found to increase hair growth in some patients.

Does minoxidil work for over 50? ›

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of topical minoxidil in the elderly. However, studies have shown that the medicine works best in younger patients who have a short history of hair loss.

What are the dangers of minoxidil? ›

Stop using this medication and tell your doctor right away if you have any serious side effects, including: unwanted facial/body hair, dizziness, fast/irregular heartbeat, fainting, chest pain, swelling of hands/feet, unusual weight gain, tiredness, difficulty breathing especially when lying down.

What are the dangers of HGH? ›

High levels of human growth hormone over a long period can produce irreversible acromegaly, but even smaller doses can lead to complications such as heart disease and diabetes. And because these hormones must be taken as injections, there are further administration risks such as a blood clot or dose error.

What happens when you stop using HGH? ›

Psychological symptoms of GH withdrawal, reported in interviews at end-point by placebo-treated patients, included decreased energy, and increased tiredness, pain, irritability and depression.

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